系主任 - 元培醫學檢驗生物技術系

姓名

楊宏基 Yang, Hung-Chi

職稱

副教授兼系主任

學歷

韋恩州立大學生化分生學系博士

電話

03-5381183 ext.8163

研究室

H308細胞分生實驗室

E-mail

hcyang@mail.ypu.edu.tw

專長

秀麗隱桿線蟲 (C. elegans)、蠶豆症(Favism)、代謝體學 (Metabolomics)、分子醫學診斷 (Moleculardiagnostic)、自由基生物醫學 (Redox Biology & Medicine)、細菌抗藥性 (Bacterial drug resistance)

經歷

中山醫學大學醫事技術學系學士
中山醫學大學醫學研究所碩士
國軍桃園總醫院病理檢驗科醫檢師
美國韋恩州立大學生化分生學系博士
長庚大學醫學生物技術暨檢驗學系博士後研究員
長庚大學健康老化中心助理研究員

相關研究計畫與論文

（A）榮譽獎項

醫技系獲國際獎金牌，2025曼谷國際發明展

（B）學術期刊論文

1. Cheng-Yeu Wu, Scott Davis, Neekita Saudagar, Shrey Shah , William Zhao, Arnold Stern, Jan Martel,
David Ojcius, and Hung-Chi Yang (2024, Jun). Caenorhabditis elegans as a Convenient Animal Model
for Microbiome Studies. International Journal of Molecular Sciences, 25, 6670.
2. Yu-Tze Horng, Novaria Sari Dewi Panjaitan, Yi-Jhen Tsai, Pin-Wei Su, Hung-Chi Yang, Po-Chi Soo
(2023, Aug). The role of EII complex in the bacterial responses to the glucose-survey in clinical
Klebsiella pneumoniae isolates. PLoS One .
3. Pei-Yun Lin, Shang-Yih Chan, Arnold Stern, Po-Hsiang Chen, Hung-Chi Yang (2023, Feb).
Epidemiological profiles and pathogenicity of Vancomycin-resistant Enterococcus faecium clinical
isolates in Taiwan. PeerJ.
4. Wan-Hua Yang, Po-Hsiang Chen, Hung-Hsin Chang, Hong Luen Kwok, Arnold Stern, Po-ChiSoo,
Jiun-Han Chen, Hung-Chi Yang (2023, Jan). Impaired immune response and barrier function in GSPD1-deficient C. elegans infected with Klebsiella pneumoniae. Current Research in Microbial Sciences,
4, 100181.
5. Pei-Yun Lin, Arnold Stern, Hsin-Hsin Peng, Jiun-Han Chen and Hung-Chi Yang (2022, Nov). Redox
and Metabolic Regulation of Intestinal Barrier Function and Associated Disorders. International
Journal of Molecular Sciences , 2022, 23, 14463. (SCI).
6. Po-Hsiang Chen, Wen-Ye Tjong, Hung-Chi Yang, Hui-Ya Liu, Arnold Stern, Daniel Tsun-Yee Chiu
(2022, Feb). Glucose-6-Phosphate Dehydrogenase, Redox Homeostasis and Embryogenesis.
International Journal of Molecular Sciences. (SCI).
7. Yu-Tze Horng, Novaria Sari Dewi Panjaitan, Hui-Ju Chang, Yu-Hong Wei, Chih-Ching Chien, HungChi Yang, Heng-Yuan Chang, Po-Chi Soo (2021, Nov). A protein containing the DUF1471 domain
regulates biofilm formation and capsule production in Klebsiella pneumoniae. Journal of
Microbiology, Immunology and Infection.
8. Pei-Yun Lin, Hio-Cheng Lau, Arnold Stern, Qian-Hong Ye, Kan-Jen Tsai, Hung-Chi Yang (2021, Jul).
Antibiotic Resistance in Bacteria: Mechanisms and Antibiotic Susceptibility Testing Methodologies.
Journal of Biomedical and Laboratory Sciences.
9. Hung-Chi Yang, Arnold Stern, Daniel Tsun-Yee Chiu (2021, Jun). G6PD: A hub for metabolic
reprogramming and redox signaling in cancer. Biomed journal. (SCI).
10. Hung-Chi Yang, Tian-Hsiang Ma, Wen-Ye Tjong, Arnold Stern, Daniel Tsun-Yee Chiu (2021, Apr).
G6PD deficiency, redox homeostasis, and viral infections: implications for SARS-CoV-2 (COVID19). Free Radical Research. (SCI).
11. Novaria Sari Dewi Panjaitan, Yu-Tze Horng, Chih-Ching Chien, Hung-Chi Yang, Ren-In You, Po-Chi
Soo (2021, Feb). The PTS Components in Klebsiella pneumoniae Affect Bacterial Capsular
Polysaccharide Production and Macrophage Phagocytosis Resistance. Microorganisms . (SCI).
12. Pei-Yun Lin, Wai-Wa Lai, Arnold Stern, Kan-Jen Tsai, Qian-Hong Ye, Hung-Chi Yang (2020, Dec).
The Gut Microbiota in Human Health and Disease: From Brain-Gut Axis Testing Methodologies to
Therapeutic Approaches. Journal of Biomedical and Laboratory Sciences.
13. Hung-Chi Yang, Hsiang Yu, Tian-Hsiang Ma, Wen-Ye Tjong, Arnold Stern, Daniel Tsun-Yee Chiu
(2020, Nov). tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects
Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans. International
Journal of Molecular Sciences, 2020, 21, 8688. (SCI).
14. Hsu-Feng Lu, Bo-Kuan Wu, Yi-Wei Huang, Ming-Zhe Lee, Ming-Fang Li, Hsu-Jung Ho, Hung-Chi
Yang, Tsuey-Ching Yang (2020, Oct). PhoPQ two component regulatory system plays a global
regulatory role in antibiotic susceptibility, physiology, stress adaptation, and virulence in
Stenotrophomonas maltophilia. BMC Microbiology, (2020) 20:312. (SCI).
15. Jan Martel, Cheng-Yeu Wu, Hsin-Hsin Peng, Yun-Fei Ko, Hung-Chi Yang, John D. Young and David
M. Ojcius (2020, Sep). Plant and fungal products that extend lifespan in Caenorhabditis elegans.
Microbial cell. (SCI).
16. Pei-yun Lin, Arnold Stern, Hung-chi Yang (2020, Mar). Dissecting anti-cancer and anti-aging
mechanisms via the C. elegans-microbiota-drug interaction. Journal of Biomedical and Laboratory
Sciences. (SCI).
17. Hung-Chi Yang, Yi-Hsuan Wu, Wei-Chen Yen, Hui-Ya Liu, Tsong-Long Hwang, Arnold Stern and
Daniel Tsun-Yee Chiu (2019, Sep). The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer.
Cells, 2019, 8, 1055. (SCI).
18. Wan-Hua Yang, Chia-Yi Chen, Kun-Liang Wang, Hong Luen Kwok, Arnold Stern, Szecheng J. Lo,
Hung-Chi Yang (2019, Aug). Reflex and habituation behavior of Caenorhabditis elegans assessed by
a mechanical vibration system and image analysis. Journal of Neuroscience Methods, 328 (2019)
108415.(SCI).
19. Hung-Chi Yang, Hsiang Yu, You-Cheng Liu, Tzu-Ling Chen, Arnold Stern, Szecheng J. Lo and Daniel
Tsun-Yee Chiu (2019, Jan). IDH-1 deficiency induces growth defects and metabolic alterations in
GSPD-1-deficient Caenorhabditis elegans. Journal of Molecular Medicine. (SCI).